"You can't help getting older, but you don't have to get old." said
George Burns who lived well into his nineties. Aging, unfortunately, is a
part of life. How we age is now, readily becoming a fate we place in
our own hands. On the predictions of Francis Bacon, Rene Descartes, and
Benjamin Franklin, the science of anti-aging has become an art.
Unfortunately less than 1% of MD's and 1/2% of nurses have received
training dealing with the special needs of older adults.
Instead
of searching for the ever illusive "fountain of youth", millions of
Americans are slowing their own biological clocks with the proven
methods of today's latest research. While genetic make-up and the
world's environmental influences will still affect the aging process,
never before have so many had the chance to fight father time and extend
their life.
Aging used to be inevitable and while some degree of
aging still is, the information found on these and the following pages,
offers some insight to the many fantastic breakthroughs in the science
of anti-aging.
Rising life expectancy means members of the huge
baby boom generation who are nearing old age, can look forward to more
golden years than their parents. With aging prevention is key. Start
your own journey to a younger feeling and healthier you.
The Key to Anti-Aging: Telomeres
Robert
Browning wrote, "Grow old with me, the best is yet to be" more than 100
years ago. At that time, it may have well been very true. Even twenty,
or ten, years ago that still held true. As the dawn rises on a new
millennium amazing new advances in science and technology are occurring
along with a shift in public consciousness, make it possible to now
control the aging process.
Over the recorded existence of man the
average human life span has increased. This increase is owed to
improvements in medical care, including the use of antibiotics,
improvements in housing, education and sanitation. However, there
appears to be a maximum, or fixed, end point. Recent research reports
have indicated that the aging process itself could indeed be modified.
Evidence for this comes from the isolation of "longevity genes", as well
as the effect on cell longevity by modification of the ends of the
chromosomes (the telomeres), elimination of treacherous free radicals,
glucose cross-linking of proteins, and the effect of hormones and
protective enzymes.
Human cells have a limited life span. In a
test tube a normal human cell will divide about 50 times and then dies
of old age. This seems to put a ceiling on the human life span. The
culprits are telomeres-minute units at the end of the DNA chain. Each
time a cell divides it must duplicate its DNA. This process results in
the shortening of the telomeres. After about 50 such replications the
telomeres are gone, and the cell loses its ability to divide.
Howard
Cooke of the Medical Research Council in Edinburgh, documented the
first connection between aging and telomeres. He noticed that the
telomeres in reproductive cells were longer than those in shorter-lived
somatic cells (the kind found in muscle, skin and nerve tissue). He
suggested that ever-shortening telomeres might determine a cells
life-span. In other words, he proposed that the telomere length offered a
clock for telling a cell's longevity.
In a barrage of papers
published over the last few years, researchers have shown that the
telomerase gene can be activated in human cells, and that it does extend
cell life. The initial development was a report in the August 15, 1997,
issue of Science. A group headed by Nobel laureate Thomas Cech, of the
University of Colorado at Boulder, and colleagues at Geron Corporation,
had isolated the human gene for a catalytic protein called telomerase
reverse transcriptase (hTRT).
hTRT is only present in immortal
cells, whereas the gene for telomerase is pre-sent in all cells. hTRT
serves to fuse the repeating sequences of DNA to the chromosomes,
thereby lengthening the telomeres. Proof that introduction of the hTRT
gene into mortal cells would cause them to produce active telomerase was
offered in the December 1, 1997, issue of Nature Genetics by the Geron
group, in a collaboration with researchers from the University of Texas
Southwestern Medical Center in Dallas.
Telomerase is a
rarely-expressed enzyme believed to play a key role in the regulation of
cell life span, functioning as part of a molecular clock of cell aging.
Its absence imparts mortality to some cells and its presence imparts
replicative immortality to others.
"Reconstituting telomerase
activity, especially in normal human cells, is a major milestone in
telomerase biology that has widespread implications for the treatment of
cancer and age-related diseases," said Jerry Shay, Ph.D., professor of
cell biology at the University of Texas Southwestern Medical Center in
Dallas.
"Since cell senescence contributes to age-related
disorders and limits the efficacy of cell and gene therapies, the
ability to extend the life span of normal cells would have broad
therapeutic and commercial impact," stated Ronald Eastman, Geron's
President and Chief Executive Officer.
While the effect this will
have on the general public is still yet undetermined, according to Jerry
Shay Ph.D., "Telomerase will allow us to take a person's own cells,
manipulate and rejuvenate them, and give them back to the same patient.
The rejuvenated cells could help grow new skin for burn victims and cure
diseases caused by the failure of aging cells to divide, such as
macular degeneration."
For the first time in history, control of
the aging process lies in the hands of mankind. How we will respond to
that challenge is still an open question. But one thing is certain, for
the generations just being born, living to be 100 will be routine.
The Ultimate Spare Part: Stem Cells
In
July 1997, a researcher from Johns Hopkins Medical Institute announced
that he had human stem cells growing in a lab dish. That announcement,
following close on the heels of Dolly (the cloned sheep), represents
another step towards a brave new world of high-tech reproduction. The
most exciting leap in this race is that while Dolly grew into a very
normal looking sheep, the stem cells in professor John Gearhart's petri
dish, should be able to develop into any cell in the human body.
Umbilical
cord blood stem cells are considered a medical breakthrough and have
been in the news recently in terms of advancements in health, science,
transplant medicine, women's health and disease treatments such as
Hodgkin's disease, lymphoma and leukemia. Future applications and
research are in areas of gene therapy and autoimmune diseases;
rheumatoid arthritis, multiple sclerosis, lupus and other immune system
disorders.
Gearhart says, "We clearly had evidence for human stem
cells. They've been able to differentiate into several tissue types in a
dish." Move over Dolly, stem cells are truly the ultimate spare part.
Sleep: one of the most important functions
"Early
to bed, early to rise, makes a man, healthy, wealthy and wise," states
the nursery rhyme, but for many older Americans, "early to rise" may be a
familiar, although troubling, part of their daily routine.
One of
the most common complaints among the aging is that of sleep difficulty.
In a study completed by the National Institute on Aging, of 9000
persons aged 65 years and older, over one half of the men and women
reported at least one chronic sleep complaint. Typical sleep problems as
we age include difficulty falling asleep, maintaining sleep, early
morning awakening, and excessive daytime sleepiness.
Melatonin
secretion is involved in physiologic sleep onset. We produce melatonin
abundantly until puberty, and then it declines steadily into old age,
thus causing the associated sleep deficiencies.
Chronic sleep
loss, according to Dr. Eve Van Cauter, may speed the onset or increase
the severity of age related conditions such as type 2 diabetes, high
blood pressure, obesity, and memory loss.
Several generalizations
can be made regarding aging and sleep characteristics. Compared with
younger persons, as we age we tend to achieve less total nighttime
sleep. Nevertheless, it cannot be assumed that older people require less
sleep. Overall, the sleep-wake cycle in the elderly is fragmented, thus
causing them to have more nighttime arousal's and awakenings. Although a
mild deterioration in sleep quality may be a normal part of the aging
process, complaints of significantly disrupted nighttime sleep, or
impaired daytime functioning because of excessive sleepiness, must be
addressed.
The Obesity Epidemic
Since 1991 the United States
has seen a drastic increase in the number of obese citizens, according
to a report in an issue of the Journal of the American Medical
Association. The study's author wrote, "the obesity epidemic has spread
with the speed and dispersion characteristic of a communicable disease
epidemic".
A decade ago 1 in every 4 Americans was seriously
overweight. Today it is 1 in 3, and climbing. Obesity is a disease that
affects at least 70 million Americans; more than one-third of all adults
and one in every five children. Many of today's obese are elderly. As
many as 3 million of Americans aged 65 and over have weight problems.
Each year, obesity causes at least 300,000 deaths and costs the country
more than $100 billion.
In today's society the terms obesity and
overweight are often interchanged in daily conversations, but they mean
two different weight states. The term obesity refers to an excess of
body fat sufficient to impair health, function or longevity. Obesity is
most often defined as being 20% or more over your ideal body weight.
Using this definition, obesity affects an estimated 70 million
Americans. Obesity is a common condition, which can have profoundly
negative health and social consequences, and is considered a serious
disease that has been linked to shortened life expectancy. According to
C. Everett Koop, former Surgeon General of the United States, obesity is
the second leading cause of preventable death in America today.
Obesity
is an independent risk factor or aggravating agent for more than 30
medical conditions including diabetes, bad knees, high blood pressure,
hardening of the arteries, and increased blood cholesterol.
How to figure your B.M.I. Index
The
following table of Body Mass Index (BMI) will help you determine your
own BMI. BMI is calculated by taking a person's weight in kg
(kg=pounds/2.2) and dividing by the persons's height in meters squared
(meters=inches x 0.0254).
Find the row that most closely matches
your weight in pounds. Read across the row until it crosses the column
that most closely matches your height in feet and inches. If you find
yourself in a cell that is dark red (BMI Greater or equal to 30 kg/m2),
then you may be a candidate for weight reduction therapy. If the cell is
pink (BMI greater or equal to 27 kg/m2 and less than 20 kg/m2) then you
may be a candidate if you have other risk factors, as mentioned in the
obesity article.
BMI 5'0" 5'3" 5'6" 5'9" 6'0" 6'3"
140# 27 25 23 21 19 18
150# 29 27 24 22 20 19
160# 31 28 26 24 22 20
170# 33 30 28 25 23 21
180# 35 32 29 27 25 23
190# 37 34 31 28 26 24
200# 39 36 32 30 27 25
210# 41 37 34 31 29 26
220# 43 39 36 33 30 28
230# 45 41 37 34 31 29
240# 47 43 39 36 33 30
250# 49 44 40 37 34 31
140# 27 25 23 21 19 18
150# 29 27 24 22 20 19
160# 31 28 26 24 22 20
170# 33 30 28 25 23 21
180# 35 32 29 27 25 23
190# 37 34 31 28 26 24
200# 39 36 32 30 27 25
210# 41 37 34 31 29 26
220# 43 39 36 33 30 28
230# 45 41 37 34 31 29
240# 47 43 39 36 33 30
250# 49 44 40 37 34 31
How Fat Affects Us
* Lungs -
In overweight people an increased body volume must be supplied with
oxygen by lungs that have not correspondingly increased in size. In
addition, the presences of thick pads of fat in the abdomen restricts
breathing. Anesthetic risk in increased in overweight patients. Being
overweight can be a special problem for asthmatics.
* Diabetes - Diabetes is more common in overweight patients than in patients of normal weight. In one group of studies, 70-80% of diabetics had a history of obesity. When an overweight diabetic loses weight, the diabetes often improves.
* Pregnancy - being overwight can be a factor in producing difficult and prolonged labor due to abnormal positioning of the fetus. This can cause fetel distress, which, in turn, may complicate labor and delivery. In addition, severely overweight women have more difficult pregnancies and an increased occurrence of maternal and infant deaths.
* Sugery - Surgical procedures are more difficult in overweight individuals due to the very bulk of the adipose tissues.
* Hernia - Certain types of hernias, involving displacement of the upper part of the stomach into the chest cavity, are more prevalent in overweight individuals than in those of normal weight.
* Joint-Disease - A vicious cycle is set up in overweight patients with arthiritis of the hip, knees, or feet, or in those who suffer from a ruptured intervertebral disc. Increased weight leads to greater wear and tear on these joints, which may become more irritated and painful. The increased discomfort forces the patient to become less and less active, thereby favoring further gain in weight.
* Adipose Tissue - Adipose (fat) tissue is composed of highly elastic cells that contain varying amounts of fatty deposits acquired via the bloodstream. Adipose tissue occurs throughout the body, covering vital organs and muscles. Overweight people have excessive fat deposits on virtually all soft organs and tissues. The number of fat cells present, and the amount of fat they contain, determines the degree of overweight.
* Blood Pressure - High blood pressure (hypertension) occurs more frequently in overweight people. Since hypertension can result in varying degrees of damage to the brain (stroke) and kidneys (degeneration), as well as the heart, it is essential that hypertensive overweight patients lose weight.
* Heart - Because the heart must supply nutrients to all tissues of the body, the greater the body mass, the greater the strain on the heart. Overweight people have a higher incidence of heart disease, the nations number oen killer.
* Atherosclerosis - Atherosclerosis is the deposit of fatty material on the lining of the arterial wall. It can result in the rupture of the blood vessel or in narrowing of these vessels, which may lead to stroke or heart attack. Studies show that there is a marked increase in the occurrence of atherosclerosis in overweight people.
* Gallbladder - a significantly higher incidence of gallbladder disease is observed in overweight patients than in those of normal weight. In one study, 88% of the patients operated on for gallstones were found to be overweight.
* The Omentum - the "pot bellied" appearance of many individuals is prmarily the result of fat accumulating within the abdominal cavity (omentum).
* Baby Fat - No type of fat, baby or otherwise, is cute. The fat cells produces by childhood weight-gain remain throughout life and can make it difficult to lose weight as an adult.
* Diabetes - Diabetes is more common in overweight patients than in patients of normal weight. In one group of studies, 70-80% of diabetics had a history of obesity. When an overweight diabetic loses weight, the diabetes often improves.
* Pregnancy - being overwight can be a factor in producing difficult and prolonged labor due to abnormal positioning of the fetus. This can cause fetel distress, which, in turn, may complicate labor and delivery. In addition, severely overweight women have more difficult pregnancies and an increased occurrence of maternal and infant deaths.
* Sugery - Surgical procedures are more difficult in overweight individuals due to the very bulk of the adipose tissues.
* Hernia - Certain types of hernias, involving displacement of the upper part of the stomach into the chest cavity, are more prevalent in overweight individuals than in those of normal weight.
* Joint-Disease - A vicious cycle is set up in overweight patients with arthiritis of the hip, knees, or feet, or in those who suffer from a ruptured intervertebral disc. Increased weight leads to greater wear and tear on these joints, which may become more irritated and painful. The increased discomfort forces the patient to become less and less active, thereby favoring further gain in weight.
* Adipose Tissue - Adipose (fat) tissue is composed of highly elastic cells that contain varying amounts of fatty deposits acquired via the bloodstream. Adipose tissue occurs throughout the body, covering vital organs and muscles. Overweight people have excessive fat deposits on virtually all soft organs and tissues. The number of fat cells present, and the amount of fat they contain, determines the degree of overweight.
* Blood Pressure - High blood pressure (hypertension) occurs more frequently in overweight people. Since hypertension can result in varying degrees of damage to the brain (stroke) and kidneys (degeneration), as well as the heart, it is essential that hypertensive overweight patients lose weight.
* Heart - Because the heart must supply nutrients to all tissues of the body, the greater the body mass, the greater the strain on the heart. Overweight people have a higher incidence of heart disease, the nations number oen killer.
* Atherosclerosis - Atherosclerosis is the deposit of fatty material on the lining of the arterial wall. It can result in the rupture of the blood vessel or in narrowing of these vessels, which may lead to stroke or heart attack. Studies show that there is a marked increase in the occurrence of atherosclerosis in overweight people.
* Gallbladder - a significantly higher incidence of gallbladder disease is observed in overweight patients than in those of normal weight. In one study, 88% of the patients operated on for gallstones were found to be overweight.
* The Omentum - the "pot bellied" appearance of many individuals is prmarily the result of fat accumulating within the abdominal cavity (omentum).
* Baby Fat - No type of fat, baby or otherwise, is cute. The fat cells produces by childhood weight-gain remain throughout life and can make it difficult to lose weight as an adult.
Nutrition For Life
As
we approach the 21st century, there is even greater focus on the baby
boom generation. Baby boomers are a key factor in the statistics that
the elderly will comprise a much larger share of the population.
According to Food Insight, in 1980 one in ten persons were age 65 or
older. By 2030, the 65 and older number will be one in five. In the year
2011 the first "boomers" will reach age 65.
Most projections say
the median age of death in the next century will climb to 84. Currently
the median life span is 73 years. Due to the latest in anti-aging
research, life spans are now being extended to ensure that the second 50
years are healthier, creating more quality and enjoyment
According
to Ann W. Sorenson, Ph.D., health science administrator at the National
Institute on Aging, "we don't have a good handle on nutrient
performance for older people." Most experts agree that the dietary needs
of people in their 50s or 60s are different from people in their 70s
and 80s.
Irwin B. Rosenberg, M.D., stated "the challenge we face
is to maintain a higher degree of physiologic performance throughout the
life cycle so that the individuals in our society are more independent,
more mobile, more able to take care of themselves." Diet and nutrition
are going to be very important aspects of health patterns in which there
can be intervention.
Many chronic diseases that develop late in
life can be linked to earlier poor eating habits. Insufficient exercise
and calcium intake during adolescence and early adulthood significantly
increase the risk of osteoporosis, which causes bones to be brittle, and
crack or break. However, good diet in later years can lessen the
effects of diseases such as osteoporosis, obesity, high blood pressure,
heart disease, certain cancers, gastrointestinal problems and chronic
under-nutrition.
Having a good diet in later years contributes to a
higher quality of life, enabling older people to maintain their
independence by continuing to perform basic daily activities such as
bathing, dressing and eating. On the other hand poor nutrition increases
the recovery time from illness, increases the possibility of
institutionalization, and creates poor quality of life.
The
American Dietetic Association states that, as you age, minerals are lost
in your bones causing osteoporosis to develop. Bones break easily and
take longer time to heal. It can develop in any man or woman. There are
several ways to protect and strengthen your bones, for example walking
makes bones strong, calcium intake needs to be high, along with getting
enough vitamin D. An article in Newsweek stated that among those at
greatest risk for vitamin D deficiencies are the elderly, alcoholics,
and people living in sun-poor climates. Studies suggest that vitamin D
may also protect against cancer. Typically as we age we tend to get less
exposure to the sun, causing reduced capacity for synthesis of vitamin
D, which is necessary for proper calcium absorption.
For a variety
of reasons, according to Food Insight, the sense of taste and smell
decline as we age. This is the result of disease, injury, drug
treatments, as well as normal aging. Susan Schiffman, Ph.D. states that a
reduction of overall quality of life is experienced, creating increased
depression, stress, and poor nutrition. In extreme cases, older people
can become anorexic.
The U.S. Food and Drug Administration states,
chewing problems are also associated with aging, causing people to lack
certain foods in their diets. Gastrointestinal disturbances, such as
constipation, diarrhea, and heartburn, are also attributed to poor
nutrition. Supplements are suggested to keep your body functioning
properly. Through appropriate lifestyle, the degenerative biological
changes associated with old age can, in many cases, be arrested.
Poor
nutrition worsens the impact of chronic disease, reduces resistance to
infections, slows healing, and increases use of the healthcare system.
Nutrient density can be increased by nutritional supplements.
Traditionally, pills and painful shots were your options. Using the
concept of oral absorption, through spray vitamins and nutraceuticals,
today's technology has created a revolutionary, convenient alternative
to maintaining adequate levels of nutrients. Spray vitamins and
nutraceuticals are up to 90 percent effective, allowing your body to
obtain the necessary nutrients. Pills contain fillers and binders. Such
as talcum powder, yeast, starch, sugar, wax and shellac. In comparison
to sprays, pills are only 10 to 50 percent effective.
How are pills made?
Makers
of pills, tablets, or caplets have standard size molds for the precise
size of their pill. It does not matter what the active ingredients are
because the manufacturer will add fillers, binders, waxes, and other
excipients to take up the space. A filler does nothing more than take-up
volume. Some common fillers are talcum powder, sugar, whey and yeast.
If
a company claims it does not use any of these common fillers, then they
surely use dehydrogenated animal fat. They have to use something to
fill up the space within the mold. Also they must use wax or some kind
of binders to make the components stick together when they squeeze
everything to make the pill.
The molds must be sprayed with a
releasing agent which is another form of wax or grease to allow the pill
to drop out of the mold. Some tablets are coated with a shiny coating.
This is normally shellac-the same as used on wood floors and boats! Time
release capsules are made of a mixture of shellac, fillers and 200
proof alcohol. There is a little bit of active ingredient and fillers
coated with the shellac/alcohol mixture. The percentage of alcohol
controls the time the pill takes to dissolve in the stomach.
Normal
tablets must meet U. S. Pharmacopeia (U.S.P.) standards. U.S.P.
standards require that tablets must dissolve within 15 to 30 minutes
once in your stomach. To test your tablets, place white vinegar in a
dish or glass and drop in your pill. Check periodically. It should
dissolve(disappear) within 15 to 30 minutes to meet U.S.P. standards. If
it doesn't, then you are paying a high price for fillers! You can keep
this test up for 45 to 60 minutes, but if the pill is not dissolved by
then, it can't possibly generate any benefit to your body.